The human growth hormone (GH or HGH) or somatotropin is a hormone that is produced in the anterior pituitary. Its main function is to stimulate the production and release of growth factors. The growth hormone affects only a few types of cells. It has a direct effect on cells in tissues. One of the effects of growth hormone is the production of insulin-like growth factor which is IGF-1. This is partly a constructive role in bone growth.
At the age of 30, people have spent most of their lives with fairly high levels of human growth hormone (HGH). Human growth hormone (HGH) is responsible for growth during childhood and for the repair and regeneration of human tissue throughout our lives. By the time we reach the age of 30, our HGH levels are only about 20 percent of their peak levels during childhood, and after the age of 30, they continue to decline at about 12 to 15 percent per decade, and often much more. By the time most of us are 30 years old, our bodies no longer produce enough HGH (human growth hormone) to repair all of the damage that is occurring in our bodies. As our HGH levels continue to decline, the damage that we call aging continues to accelerate.
The Human Growth hormone is not produced evenly but in short peaks. The growth hormone production takes place at exercise, stress, and about two hours after falling asleep. The issue is regulated in the brains by two substances, "growth hormone releasing hormone or GHRH and somatostatin. They come through special blood vessels in the pituitary gland. "Growth hormone releasing factor" has the function of stimulating the release, while somatostatin inhibits correct the issue. In the case of a shortage of growth hormone, there is growth hormone deficiency. In an over production of growth hormone, there is gigantism or acromegaly. Because one after puberty is grown on the hands, feet, jaw, and after this disease is characterized by an increase in the size of the hands and feet, or an excessive growth of the jaw. Also, increase in size the organs. The over production of growth hormone in these patients is caused by a tumor in the pituitary gland which remains continuously produce growth hormone.
Somatropin is recombinant human growth hormone (HGH) used for the treatment of growth failure in children and GH deficiency in adults. Recombinant DNA is made through a laboratory process known as molecular cloning. It requires the existence of a cloning vector, a DNA molecule capable of replicating within living cells. Vectors are typically obtained from plasmids or viruses and the choice of the one for cloning is determined base on the host organism. A piece of DNA is inserted into the vector with a marker on it for easy identification of recombinant molecules. Recombinant human growth hormone (HGH) has full biological activity when compared to a standard.
The human growth hormone (HGH) are produced by various organs and body tissues, but mainly by the endocrine glands, such as the pituitary, thyroid, and gonads. Each gland apparently synthesizes several kinds of hormones the adrenal glands alone produce more than 25 varieties. The total number of hormones is still unknown, but each has its unique function and its own chemical formula. After a hormone is discharged by its parent gland into the capillaries or the lymph, it may travel a circuitous path through the bloodstream to exert influence on cells, tissues, and organs far removed from its site of origin.